Research and development ability of HUAPONT
HUAPONT Company emphasizes research and development ability since the beginning of foundation, more than 10% of profit every year is invested in R&D Department. With twenty years of rapid developing, a multifunctional and advanced R&D center which meets the requirement of development of modern pharmaceutical company is playing an important role in HUAPONT. 
LOCATION AND SCALE
The R&D center is in the Headquarter of HUAPONT Company where stands at the foot of green hill (Zhaomu Mountain) and surrounded by the Botanical garden of Zhaomu Mountain. The center covers 30000m2 including Synthesis labs, Analysis labs, Dosage form labs, Toxicology labs, Pharmacology labs, pilot plants for API and dosage form, and other labs.
PERSONNEL AND EQUIPMENT
At present, more than 100 professional employees with high education are working in center, 10% of them are Ph.D. degree, 30% of them have the medium-grade or high grade professional tile, and 20% of them have obtained the qualification of licensed pharmacist. in addition, the hardware construction also is build up in accordance with the new policies and requirements, like elemental impurity, Genotoxicity impurity, particle size, polymorph, dissolution and so on; except the general analytical equipment like HPLC, GC, IR, UV, more advanced and large precise analytical equipment, ICP, GC/MS, LC/MS, XPRD, AAS, etc. are introduced and solved more difficulties in research of APIs or drugs. So far R&D center possesses analytical equipment which the value is more than $10,000,000, and refers to appendix for the details and some photos of analytical equipment.  
ORGANIZATION
According to the purpose of developing and researching APIs and drugs, and refer to relative regulations, an integrated and reasonable system is established. The organization chart of R&D center is as below:
 
TECHNICAL ADVANTAGES
From API to final drug, the corresponding researches are covered by R&D center, developing new API and new Preparation, applying for approval for all APIs and Preparations, and transferring the technology to facility. Meanwhile based on the advanced analytical equipment and high quality researcher group, R&D center has established four research and development drug platforms: APIs, FDF, Analysis and Pharmacology. For APIs, HUAPONT has the strong research ability and longer history of retinoids and vitamin D; for FDF, the microcrystallization of insoluble drugs and drugs for external use have great advantage. Meanwhile R&D center corporate deeply with institutes or universities to develop new projects and set up research center, for example high effective drug research center together with Chongqing University.

 
ARCHIVEMENT
Up to now the center has received 79 manufacturing approval, including 1 of new drug and 11 of 3.1 new drugs; currently 191 patents are applied, and 72 patents are authorized. Every year at least 15 new projects are running.
                                                              
 
ENDING
Innovation, passion and diligence, are the characteristics of the R&D center; it is the strong support for the company going forward. Talents and technology are the core value of HUAPONT Company.
 
Appendix: Details of analytical equipment
The regular analytical equipment are available in R&D center; for the most common and useful equipment, HPLC, GC, the center has more than forty units including SHIMADZU, AGILENT and WATER brands. With the higher demand of drug research, Except NMR (Nuclear Magnetic Resonance), more large-scale precision instrument and equipment are introduced into R&D center, the details are as below: 

Analytical Equipment

Photo

LC/MS API-3000

Supplier: AB,

Identification test for compound;

Study of pharmacokinetic profiles

and bioequivalence; study of related substances.

Matersizer 2000

Supplier: Malvern

Detect particle size distribution of API or materials in drug.

Matersizer 3000

Supplier: Malvern

Detect particle size distribution of API or materials in drug.

Gas chromatograph

Supplier: SHIMADZU

Liquid materials detection and residual solvents detection with head-space.

GC/MS

Supplier: Agilent

Quantitative analysis and qualitative analysis for samples which can be analyzed by HPLC or HPLC/MS.

X-ray diffractionmeter

Supplier: PAN ALYTICAL

Polymorph research

Automatic polarimeter

Supplier: Shanghai Jiehu Instrumentation

Detection of optical rotation for chiral compounds

TGA-DSC

Supplier: METTLER TOLEDO

Thermogravimetric analysis and Polymorph research

Preparative chromatograph (High pressure)

Supplier: SHIMADZU

Used for collecting the impurity which cannot be synthesized

Preparative chromatograph (Low pressure)

Supplier: Biotage

Used for collecting the impurity which cannot be synthesized

ICPE (Plasma Atomic Emission Spectrometer ) 9820

Supplier: SHIMADZU

Elemental impurities

AAS (Atomic Absorption Spectrophotometer)

Supplier: SHIMADZU

Elemental impurities study



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    Zip Code:401121